The Little Things Make a Big Difference Project supports a more hands-on approach for my Biology students. It was designed to introduce students to modern research techniques in the areas of cellular Biology and Genetics. Students are curious by nature. They see these crime scene investigations on television and want to do the same experiments. Students do not want to sit in a classroom taking notes all day listening to a teacher lecture. Once my students understand the topics, we began the labs. They got to see their DNA appear before their eyes. They were able to determine the identity of the criminal. By making the classroom more inquisitive, the hands-on learner can see it, touch it, smell it,etc. Students first had to learn to use the microscopes. They have prepared and made their own slides. Then students will progress through cell theory and cell division, leading into Genetics. To conclude Genetics, students will do a lab called Genes in a Bottle, leading into gel electrophoresis and finally into forensic crime scene investigation.